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Literature summary for 3.4.24.82 extracted from

  • Troeberg, L.; Fushimi, K.; Scilabra, S.D.; Nakamura, H.; Dive, V.; Thogersen, I.B.; Enghild, J.J.; Nagase, H.
    The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3 (2009), Matrix Biol., 28, 463-469.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.82

Inhibitors

Inhibitors Comment Organism Structure
N-terminal domain of tissue inhibitor of metalloproteinases-3 all isoforms of ADAMTS-4 are effectively inhibited. Inhibited more strongly by N-terminal domain of tissue inhibitor of metalloproteinases-3 than by full-length tissue inhibitor of metalloproteinases-3 Homo sapiens
tissue inhibitor of metalloproteinases-3 all isoforms of ADAMTS-4 are effectively inhibited. Inhibited more strongly by N-terminal domain of tissue inhibitor of metalloproteinases-3 than by full-length tissue inhibitor of metalloproteinases-3 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinantly expressed in Escherichia coli
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carboxyfluorescein-Ala-Glu-Leu-Asn-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lys-N,N,N',N'-tetramethyl-6-carboxyrhodamine + H2O
-
 Homo sapiens carboxyfluorescein-Ala-Glu + Leu-Asn-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lys-N,N,N',N'-tetramethyl-6-carboxyrhodamine
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS-4
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0001
-
 N-terminal domain of tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS4-3 Homo sapiens
0.00013
-
 N-terminal domain of tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS4-1 Homo sapiens
0.00018
-
 N-terminal domain of tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS4-2 Homo sapiens
0.00022
-
 tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS4-1 Homo sapiens
0.00022
-
 tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS4-2 Homo sapiens
0.0004
-
 tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS4-3 Homo sapiens
0.00051
-
 tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS4-4 Homo sapiens
0.00064
-
 N-terminal domain of tissue inhibitor of metalloproteinases-3 pH 7.5, 37°C, isoenzyme ADAMTS4-4 Homo sapiens