Inhibitors | Comment | Organism | Structure |
---|---|---|---|
doxycycline | dose-dependently inhibits the activity of rhADAMTS4 in vitro | Homo sapiens | |
minocycline | dose-dependently inhibits the activity of rhADAMTS4 in vitro | Homo sapiens | |
tetracycline | dose-dependently inhibits the activity of rhADAMTS4 in vitro | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan-interglobular domain + H2O | an aggrecan peptide with the N-terminal sequence ARGSVIL is released and quantified | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS4 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0453 | - |
doxycycline | rhADAMTS4(F213-R695), pH and temperature not specified in the publication | Homo sapiens | |
0.0611 | - |
doxycycline | rhADAMTS4(F213-A579), pH and temperature not specified in the publication | Homo sapiens | |
0.0869 | - |
minocycline | rhADAMTS4(F213-R695), pH and temperature not specified in the publication | Homo sapiens | |
0.0973 | - |
minocycline | rhADAMTS4(F213-A579), pH and temperature not specified in the publication | Homo sapiens | |
0.12 | - |
tetracycline | rhADAMTS4(F213-A579), pH and temperature not specified in the publication | Homo sapiens | |
0.761 | - |
tetracycline | rhADAMTS4(F213-R695), pH and temperature not specified in the publication | Homo sapiens |