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Literature summary for 3.4.24.82 extracted from

  • Steinmeyer, J.; Kordelle, J.; Stuerz, H.
    In vitro inhibition of aggrecanase activity by tetracyclines and proteoglycan loss from osteoarthritic human articular cartilage (2010), J. Orthop. Res., 28, 828-833.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
doxycycline dose-dependently inhibits the activity of rhADAMTS4 in vitro Homo sapiens
minocycline dose-dependently inhibits the activity of rhADAMTS4 in vitro Homo sapiens
tetracycline dose-dependently inhibits the activity of rhADAMTS4 in vitro Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan-interglobular domain + H2O an aggrecan peptide with the N-terminal sequence ARGSVIL is released and quantified Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ADAMTS4
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0453
-
doxycycline rhADAMTS4(F213-R695), pH and temperature not specified in the publication Homo sapiens
0.0611
-
doxycycline rhADAMTS4(F213-A579), pH and temperature not specified in the publication Homo sapiens
0.0869
-
minocycline rhADAMTS4(F213-R695), pH and temperature not specified in the publication Homo sapiens
0.0973
-
minocycline rhADAMTS4(F213-A579), pH and temperature not specified in the publication Homo sapiens
0.12
-
tetracycline rhADAMTS4(F213-A579), pH and temperature not specified in the publication Homo sapiens
0.761
-
tetracycline rhADAMTS4(F213-R695), pH and temperature not specified in the publication Homo sapiens