Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin-1alpha | induced gene expression in osteoarthritic chondrocytes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hyaluronan | hyaluronan 800 kDA and 2700 kDa decreased IL1alpha-induced expression of aggrecanase-1 decreased | Homo sapiens | |
KB-R7785 | - |
Homo sapiens | |
TIMP3 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
articular cartilage | - |
Homo sapiens | - |
chondrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan + H2O | 100 microg/ml | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS4 | - |
Homo sapiens |
aggrecanase-1 | - |
Homo sapiens |