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Literature summary for 3.4.24.82 extracted from

  • Hills, R.; Mazzarella, R.; Fok, K.; Liu, M.; Nemirovskiy, O.; Leone, J.; Zack, M.D.; Arner, E.C.; Viswanathan, M.; Abujoub, A.; Muruganandam, A.; Sexton, D.J.; Bassill, G.J.; Sato, A.K.; Malfait, A.M.; Tortorella, M.D.
    Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate (2007), J. Biol. Chem., 282, 11101-11109.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
acetyl-DVQEFRGVTAVIRNH2
-
 Homo sapiens
acetyl-HNEFRQRETYMVF-NH2
-
 Homo sapiens
SC81956
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
 active enzyme, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
heparin-Sepharose chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan + H2O
-
 Homo sapiens fragments of aggrecan
-
 ?
DVQEFRGVTAVIR + H2O
-
 Homo sapiens ?
-
 ?
HNEFRQRETYMVF + H2O
-
 Homo sapiens ?
-
 ?
matrilin-3 + H2O cleaves at Glu435/Ala436 generating two species of 45 and 5 kDa Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloproteinase with thrombospondin motifs-4
-
 Homo sapiens
ADAMTS-4
-
 Homo sapiens
aggrecanase 1
-
 Homo sapiens