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Literature summary for 3.4.24.82 extracted from

  • Bondeson, J.; Wainwright, S.; Hughes, C.; Caterson, B.
    The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review (2008), Clin. Exp. Rheumatol., 26, 139-145.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
interleukin-1
-
Mus musculus
interleukin-1
-
Homo sapiens
interleukin-1
-
Sus scrofa
interleukin-1
-
Bos taurus
additional information not stimulated by phorbol ester Mus musculus
additional information not stimulated by phorbol ester Homo sapiens
additional information not stimulated by phorbol ester Sus scrofa
additional information not stimulated by phorbol ester Bos taurus
NFkappaB
-
Mus musculus
NFkappaB
-
Homo sapiens
NFkappaB
-
Sus scrofa
NFkappaB
-
Bos taurus
oncostatin M
-
Mus musculus
oncostatin M
-
Homo sapiens
oncostatin M
-
Sus scrofa
oncostatin M
-
Bos taurus
transforming growth factor beta
-
Mus musculus
transforming growth factor beta
-
Homo sapiens
transforming growth factor beta
-
Sus scrofa
transforming growth factor beta
-
Bos taurus
Tumor necrosis factor alpha
-
Mus musculus
Tumor necrosis factor alpha
-
Homo sapiens
Tumor necrosis factor alpha
-
Sus scrofa
Tumor necrosis factor alpha
-
Bos taurus

Application

Application Comment Organism
medicine therapeutic target in osteoarthritis Mus musculus
medicine therapeutic target in osteoarthritis Homo sapiens
medicine therapeutic target in osteoarthritis Sus scrofa
medicine therapeutic target in osteoarthritis Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage
-
Mus musculus
-
cartilage
-
Homo sapiens
-
cartilage
-
Sus scrofa
-
cartilage
-
Bos taurus
-
chondrocyte
-
Mus musculus
-
chondrocyte
-
Homo sapiens
-
chondrocyte
-
Sus scrofa
-
chondrocyte
-
Bos taurus
-
macrophage
-
Mus musculus
-
macrophage
-
Homo sapiens
-
macrophage
-
Sus scrofa
-
macrophage
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan + H2O cleaves the Glu373-Ala374 bond Mus musculus fragments of aggrecan
-
ir
aggrecan + H2O cleaves the Glu373-Ala374 bond Homo sapiens fragments of aggrecan
-
ir
aggrecan + H2O cleaves the Glu373-Ala374 bond Sus scrofa fragments of aggrecan
-
ir
aggrecan + H2O cleaves the Glu373-Ala374 bond Bos taurus fragments of aggrecan
-
ir

Synonyms

Synonyms Comment Organism
ADAMTS4
-
Mus musculus
ADAMTS4
-
Homo sapiens
ADAMTS4
-
Sus scrofa
ADAMTS4
-
Bos taurus
aggrecanase-1
-
Mus musculus
aggrecanase-1
-
Homo sapiens
aggrecanase-1
-
Sus scrofa
aggrecanase-1
-
Bos taurus