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Literature summary for 3.4.24.82 extracted from
- Aggrecanase-1 (ADAMTS-4) interacts with a1-antitrypsin (2005), Biochim. Biophys. Acta, 1725, 152-159.
Application
| Application | Comment | Organism |
|---|---|---|
| degradation | abrasion of cartilage aggrecan in rheumatoid arthritis and osteoarthritis | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Saccharomyces cerevisiae and COS-7 cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no inhibitory effect of alpha1-antitrypsin | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 42000 | - |
SDS-PAGE, active enzyme | Homo sapiens |
| 50000 | - |
SDS-PAGE, after incubation with alpha1-antitrypsin suggesting that there ADAMTS-4 has almost no proteolytic activity | Homo sapiens |
| 75000 | - |
SDS-PAGE, inactive full-length enzyme | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| articular cartilage | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | - |
Homo sapiens | fragments of aggrecan | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS-4 | - |
Homo sapiens |
| aggrecanase-1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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