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Literature summary for 3.4.24.82 extracted from
- A microplate assay specific for the enzyme aggrecanase (2003), Anal. Biochem., 314, 260-265.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| ADAMTS-4 and ADAMTS-5 | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BB-16 | 0.1 mM, complete inhibition of aggrecanase 1 and 2 | Bos taurus |  |
| EDTA | 1 mM, complete inhibition of aggrecanase 1 and 2 | Bos taurus | |
| o-phenanthroline | 1 mM, complete inhibition of aggrecanase 1 and 2 | Bos taurus | |
| SE206 | 0.1 mM, complete inhibition of aggrecanase 1 and 2 | Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.48 | - |
QTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLK | biotinylated peptide containing aggrecanase cleavage site | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
aggrecanase-1 and 2, i.e. ADAMTS-4 and 5 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cartilage | cartilage culture | Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| QTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLK + H2O | - |
Bos taurus | QTVTWPDMELPLPRNITEGE + ARGSVILTVKPIFEVSPSPLK | - |
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Release 2023.1 (January 2023)
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