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Literature summary for 3.4.24.82 extracted from
- Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4) (2002), Matrix Biol., 21, 499-511.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
| expression of ADAMTS-5 in Drosophila S2 cells | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
ADAMTS stands for: a disintegrin and metalloproteinase with thrombospondin motifs | - |
| Homo sapiens | - |
aggrecanase-2, i.e. ADAMTS-5 | - |
| Homo sapiens | O75173 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| articular cartilage | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | - |
Homo sapiens | fragments of aggrecan | - |
? |  |
| aggrecan + H2O | ADAMTS-5, i.e. aggrecanase-2 cleaves at Glu373-Ala374 | Homo sapiens | fragments of aggrecan | - |
? | |
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