Literature summary for 3.4.24.82 extracted from

Flannery, C.R.; Zeng, W.; Corcoran, C.; Collins-Racie, L.A.; Chockalingam, P.S.; Hebert, T.; Mackie, S.A.; McDonagh, T.; Crawford, T.K.; Tomkinson, K.N.; LaVallie, E.R.; Morris, E.A.
Autocatalytic cleavage of ADAMTS-4 (aggrecanase-1) reveals multiple glycosaminoglycan-binding sites (2002), J. Biol. Chem., 277, 42775-42780.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression of ADAMTS-4 in CHO/A2 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E362Q	active site mutant, no aggrecanase activity, no autocatalytic cleavage	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
68000	-	x * 68000, following incubation at 37°C for 16 h, ADAMTS-4 is detected as isoforms of 68000 Da, 53000 Da and 40000 Da	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O75173	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	autocatalytic cleavage, cleavage sites are Lys694-Phe695 and Thr581-Phe582, following incubation at 37°C for 16 h, ADAMTS-4 is detected as isoforms of 68000 Da, 53000 Da and 40000 Da	Homo sapiens

Subunits

Subunits	Comment	Organism
?	x * 68000, following incubation at 37°C for 16 h, ADAMTS-4 is detected as isoforms of 68000 Da, 53000 Da and 40000 Da	Homo sapiens

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Release 2023.1 (January 2023)