Literature summary for 3.4.24.82 extracted from

Sandy, J.D.; Westling, J.; Kenagy, R.D.; Iruela-Arispe, M.L.; Verscharen, C.; Rodriguez-Mazaneque, J.C.; Zimmermann, D.R.; Lemire, J.M.; Fischer, J.W.; Wight, T.N.; Clowes, A.W.
Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4 (2001), J. Biol. Chem., 276, 13372-13378.

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Cloned(Commentary)

Cloned (Comment)	Organism
ADAMTS-1	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	ADAMTS-1 also cleaves versican and aggrecane	-
Homo sapiens	O75173	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant ADAMTS-1	Homo sapiens
recombinant ADAMTS-4	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
aggrecan + H2O	both ADAMTS-1 and ADAMTS-4 cleave aggrecan at the Glu441-Ala442 bond	Homo sapiens	fragments of aggrecan	-	?
versican + H2O	both ADAMTS-1 and ADAMTS-4 cleave native human and recombinant versican at Glu441-A442, ADAMTS-4 is 5-10fold more active than ADAMTS-1	Homo sapiens	fragments of versican	-	?

Synonyms

Synonyms	Comment	Organism
ADAMTS-1	-	Homo sapiens

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Release 2023.1 (January 2023)