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Literature summary for 3.4.24.81 extracted from
- ADAM10 regulates transcription factor expression required for plasma cell function (2012), PLoS ONE, 7, e42694.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | O35598 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B-cell | - |
Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | upon deletion of ADAM10 in B cells, antibody responses are impaired despite normal germinal center formation in mice, implicating ADAM10 in post-germinal center and extrafollicular B cell terminal differentiation. Plasma cell numbers are normal in ADAM10 deletion mice when compared to controls. Plasma cells of the deletion strain exhibit decreased expression of transcription factors important for their function: Prdm1, Xbp1 and Irf4. Transcriptional repressor Bcl6 expression is increased in plasma cells isolated from ADAM10 deletion mice at both the mRNA and protein level | Mus musculus |
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Release 2023.1 (January 2023)
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