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Literature summary for 3.4.24.81 extracted from

  • Guo, Q.; Wang, Y.; Tripathi, P.; Manda, K.; Mukherjee, M.; Chaklader, M.; Austin, P.; Surendran, K.; Chen, F.
    Adam10 mediates the choice between principal cells and intercalated cells in the kidney (2015), J. Am. Soc. Nephrol., 26, 149-159.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
kidney
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 Mus musculus
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General Information

General Information Comment Organism
physiological function Adam10 deficiency in ureteric bud derivatives leads to a decrease in urinary concentrating ability, polyuria, and hydronephrosis. Adam10 deficiency leads to a reduction in the percentage of aquaporin 2+ principal cells in the collecting ducts that is accompanied by a proportional increase in the percentage of intercalated cells. Foxi1, a transcription factor important for the differentiation of intercalated cells, is upregulated in the Adam10 mutants Mus musculus