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Literature summary for 3.4.24.81 extracted from
- Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling (2011), Nat. Cell Biol., 13, 1100-1107.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| E-cadherin + H2O | Canis lupus familiaris | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MDCK cell | - |
Canis lupus familiaris | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| E-cadherin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM10 | - |
Canis lupus familiaris |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | inhibition of ADAM10 activity in the intestine of mice results in a lack of compartmentalization of Paneth cells within the crypt stem cell niche | Canis lupus familiaris |
| physiological function | ADAM10 activity acts continuously at sites of EphB-ephrin-B interaction to prevent the formation of E-cadherin-mediated cell adhesion. ADAM10 metalloproteinase activity is required for EphB/ephrin-B-mediated cell sorting and E-cadherin remodelling | Canis lupus familiaris |
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Release 2023.1 (January 2023)
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