Literature summary for 3.4.24.81 extracted from

Gibb, D.R.; El Shikh, M.; Kang, D.J.; Rowe, W.J.; El Sayed, R.; Cichy, J.; Yagita, H.; Tew, J.G.; Dempsey, P.J.; Crawford, H.C.; Conrad, D.H.
ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo (2010), J. Exp. Med., 207, 623-635.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CD23 + H2O	Mus musculus	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CD23 + H2O	-	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
a disintegrin and metalloproteinase 10	-	Mus musculus
ADAM10	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	deletion of ADAM10 prevents development of the entire marginal zone B cell lineage	Mus musculus
physiological function	ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. ADAM10 initiates Notch2 signaling	Mus musculus

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Release 2023.1 (January 2023)