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Literature summary for 3.4.24.81 extracted from
- Metalloprotease ADAM10 is required for Notch1 site 2 cleavage (2009), J. Biol. Chem., 284, 31018-31027.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Mus musculus | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Notch1 + H2O | Mus musculus | ADAM10 is required for site 2 cleavage of the single-pass transmembrane receptor Notch1 | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Notch1 + H2O | ADAM10 is required for site 2 cleavage of the single-pass transmembrane receptor Notch1 | Mus musculus | ? | - |
? | |
| Notch1 + H2O | ADAM10 is required for Notch1 site 2 cleavage | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM10 | - |
Mus musculus |
| kuzbanian | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ADAM10 is required for Notch1 site 2 cleavage | Mus musculus |
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Release 2023.1 (January 2023)
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