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Literature summary for 3.4.24.81 extracted from

  • Kohutek, Z.A.; diPierro, C.G.; Redpath, G.T.; Hussaini, I.M.
    ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration (2009), J. Neurosci., 29, 4605-4615.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in U-251 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information inhibition of ADAM10 expression using short interfering RNA reduces N-cadherin cleavage and decreases glioblastoma cell migration Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm in untreated cells Mus musculus 5737
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nucleus in untreated cells Mus musculus 5634
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plasma membrane treatment of the glioblastoma cells with the PKC activator phorbol 12-myristate 13-acetate (PMA) leads to the translocation of ADAM10 to the cell membrane, the site at which N-cadherin is cleaved and this translocation is significantly reduced by the PKC-alpha inhibitor Gรถ6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole] or PKC-alpha short hairpin RNA Mus musculus 5886
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte cell line N-Cadherin cleavage occurs at a higher level in glioblastoma cells than in non-neoplastic astrocytes Mus musculus
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glioblastoma cell line U-1242 MG, N-Cadherin cleavage occurs at a higher level in glioblastoma cells than in non-neoplastic astrocytes Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-cadherin + H2O treatment with the PKC activator phorbol 12-myristate 13-acetate (PMA) increases N-cadherin cleavage. And treatment of the cells with PKC-alpha inhibitor Gรถ6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole] or PKC-alpha short hairpin RNA significantly reduces N-cadherin cleavage Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
ADAM10
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Mus musculus