Cloned (Comment) | Organism |
---|---|
expressed in U-251 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | inhibition of ADAM10 expression using short interfering RNA reduces N-cadherin cleavage and decreases glioblastoma cell migration | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | in untreated cells | Mus musculus | 5737 | - |
nucleus | in untreated cells | Mus musculus | 5634 | - |
plasma membrane | treatment of the glioblastoma cells with the PKC activator phorbol 12-myristate 13-acetate (PMA) leads to the translocation of ADAM10 to the cell membrane, the site at which N-cadherin is cleaved and this translocation is significantly reduced by the PKC-alpha inhibitor Gรถ6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole] or PKC-alpha short hairpin RNA | Mus musculus | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte cell line | N-Cadherin cleavage occurs at a higher level in glioblastoma cells than in non-neoplastic astrocytes | Mus musculus | - |
glioblastoma cell line | U-1242 MG, N-Cadherin cleavage occurs at a higher level in glioblastoma cells than in non-neoplastic astrocytes | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-cadherin + H2O | treatment with the PKC activator phorbol 12-myristate 13-acetate (PMA) increases N-cadherin cleavage. And treatment of the cells with PKC-alpha inhibitor Gรถ6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole] or PKC-alpha short hairpin RNA significantly reduces N-cadherin cleavage | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAM10 | - |
Mus musculus |