Protein Variants | Comment | Organism |
---|---|---|
additional information | mouse embryonic fibroblast cells deficient of ADAM10 are not able to produce cleaved RAGE (receptor for advanced glycation endproducts). Stable transfection of MEF deficient with a plasmid coding for mouse ADAM10 is able to rescue the phenotype | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GI254023X | inhibits RAGE (receptor for advanced glycation endproducts) cleavage | Homo sapiens | |
GW280623X | inhibits RAGE (receptor for advanced glycation endproducts) cleavage | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
RAGE + H2O | a soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by ADAM10 | Mus musculus | ? | - |
? | |
RAGE + H2O | a soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by ADAM10 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAM10 | - |
Mus musculus |
ADAM10 | - |
Homo sapiens |