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Literature summary for 3.4.24.81 extracted from

  • Prinzen, C.; Truembach, D.; Wurst, W.; Endres, K.; Postina, R.; Fahrenholz, F.
    Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice (2009), BMC Genomics, 10, 66.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
molecular biology there is only a moderate alteration of gene expression in ADAM10 overexpressing mice. Genes coding for pro-inflammatory or pro-apoptotic proteins are not overrepresented among differentially regulated genes. Even a decrease of inflammation markers is observed. This further supports the strategy to treat alzheimer’s disease by increasing the beta-secretase activity Bos taurus

Protein Variants

Protein Variants Comment Organism
additional information to assess the influence of ADAM10 on the gene expression profile in the brain, a microarray analysis using RNA isolated from brains of five months old mice overexpressing either ADAM10, or a dominant-negative mutant of this enzyme. Overexpression of proteolytically active ADAM10 affects several physiological pathways, such as cell communication, nervous system development, neuron projection as well as synaptic transmission. Although ADAM10 is implicated in Notch and beta-catenin signaling, no significant changes in the respective target genes are observed in adult ADAM10 transgenic mice. RT-PCR confirms a downregulation of genes coding for the inflammation-associated proteins S100a8 and S100a9 induced by moderate ADAM10 overexpression. Overexpression of the dominant-negative form dnADAM10 leads to a significant increase in the expression of the fatty acid-binding protein Fabp7, which is found in higher amounts in brains of Down syndrome patients Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
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Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
ADAM10
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 Bos taurus