Protein Variants | Comment | Organism |
---|---|---|
additional information | using siRNA to knockdown ADAM10 in highly invasive glioblastoma cell line U251 it is shown that CD44 shedding is compromised in a dose-dependent manner | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TIMP-1 | tissue inhibitors of metalloproteinase 1, it is shown that the N-terminal domain of TIMP-1 is not sufficient for inhibition of ADAM10, 37% of ADAM10-mediated CD44 shedding is observed | Homo sapiens | |
TIMP-3 | tissue inhibitors of metalloproteinase 3, it is shown that the N-terminal domain of TIMP-3 is not sufficient for inhibition of ADAM10, 72% of ADAM10-mediated CD44 shedding is observed | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | TIMP1 and TIMP-3 (tissue inhibitors of metalloproteinase) interact and inhibit ADAM10 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | TIMP1 and TIMP-3 (tissue inhibitors of metalloproteinase) interact and inhibit ADAM10 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAM10 | - |
Homo sapiens |