Literature summary for 3.4.24.81 extracted from

Chen, C.D.; Podvin, S.; Gillespie, E.; Leeman, S.E.; Abraham, C.R.
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17 (2007), Proc. Natl. Acad. Sci. USA, 104, 19796-19801.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Insulin	0.001 mM, stimulates the cleavage of the extracellular domain of Klotho	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
EDTA	10 mM	Homo sapiens
EGTA	10 mM	Homo sapiens
additional information	TMP-1 and TIMP-2 do not inhibit shedding of Klotho by ADAM10	Homo sapiens
TAPI-1	0.05 mM	Homo sapiens
TIMP-3	-	Homo sapiens
Wortmannin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
extracellular domain of Klotho + H2O	-	Homo sapiens	130000 Da Klotho fragment + 68000 Da Klotho fragment	-	?

Synonyms

Synonyms	Comment	Organism
a disintegrin and metalloproteinase 10	-	Homo sapiens
ADAM10	-	Homo sapiens

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Release 2023.1 (January 2023)