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Literature summary for 3.4.24.81 extracted from
- Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum (2005), Mol. Cell. Biol., 25, 9324-9339.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phorbol 12-myristate 13-acetate | - |
Mus musculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2S)-N4-hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-isobutylsuccinamide | metalloproteinase inhibitor GM6001 suppresses constitutive AX1 shedding 2.8 and 3.5fold, respectively, and PMA-induced Axl shedding 2.9 and 3.2fold, respectively | Mus musculus | |
| GW280264X | i.e. (2R,3S)-3-(formyl-hydroxyamino)-2-2-methyl-1-propyl hexanoic acid [(1S)-5-benzyloxycarbamoylamino-1-(1,3-thiazol-2-ylcarbamoyl)-1-pentyl]amide, potent inhibitor | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast cell line | L929 and L929R | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM10 | disintegrin-like metalloproteinase 10 | Mus musculus |
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Release 2023.1 (January 2023)
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