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Literature summary for 3.4.24.81 extracted from
- Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase (2006), J. Neurosci. Res., 84, 106-118.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| interleukin-1alpha | 2 ng/ml stimulates ADAM-10 level 2.1 fold after 16h treatment | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | strain U373 MG | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-amyloid precursor protein + H2O | - |
Homo sapiens | sAPP-alpha fragment + C-terminal fragment | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM-10 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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