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Literature summary for 3.4.24.81 extracted from
- ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced a-secretase cleavage of amyloid precursor protein (2006), J. Biol. Chem., 281, 16419-16427.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | pharmacotherapeutic target for the treatment of cerebral amyloidosis in Alzheimer disease | Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
SDS-PAGE, mature active form of ADAM10 | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| microglia | - |
Mus musculus | - |
| neuronal cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-amyloid precursor protein + H2O | - |
Mus musculus | sAPP-alpha fragment + C-terminal fragment | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM10 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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