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Literature summary for 3.4.24.81 extracted from

  • Colciaghi, F.; Borroni, B.; Pastorino, L.; Marcello, E.; Zimmermann, M.; Cattabeni, F.; Padovani, A.; Di Luca, M.
    alpha-secretase ADAM10 as well as aAPPs is reduced in platelets and CSF of Alzheimer Disease patients (2002), Mol. Med., 8, 67-74.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.81

Application

Application Comment Organism
medicine reduction of ADAM10 in Alzheimer disease could allow beta-secretase cleavage of amyloid precursor protein Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-amyloid precursor protein Homo sapiens platelet and cerebrospinal fluid have lower levels of alpha-APP in Alzheimer patients sAPP-alpha fragment + C-terminal fragment
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
SDS-PAGE Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet lower levels of ADAM10 in Alzheimer disease Homo sapiens
-
cerebrospinal fluid
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-amyloid precursor protein platelet and cerebrospinal fluid have lower levels of alpha-APP in Alzheimer patients Homo sapiens sAPP-alpha fragment + C-terminal fragment
-
 ?