Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | - |
Mus musculus | |
additional information | cells overexpressing ADAM10 are not responsive to phorbol ester-induced cleavage, indicating constitutive activity and not Protein kinase C induced activity | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | cleavage by metalloproteinase ADAM10 of PrP cellular protein is constitutive and could inhibit the maintenance of the toxic core of the protein PrP scrapie in spongiform encephalopathies | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BB3103 | 0.01 mM inhibitory but not completely | Homo sapiens | |
BB3103 | 0.01 mM inhibitory but not completely | Mus musculus | |
additional information | serine, thiol and acidic protease inhibitors are not inhibitory | Homo sapiens | |
additional information | serine, thiol and acidic protease inhibitors are not inhibitory | Mus musculus | |
o-phenanthroline | inhibit activity 0.1 mM | Homo sapiens | |
o-phenanthroline | inhibit activity 0.1 mM | Mus musculus | |
TAPI | 0.01 mM inhibitory but not completely | Homo sapiens | |
TAPI | 0.01 mM inhibitory but not completely | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell associated | - |
Mus musculus | - |
- |
cell associated | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cellular prion protein | Mus musculus | constitutive protein cleavage | N1 fragment + C-terminal fragment | - |
? | |
cellular prion protein | Homo sapiens | constitutive protein cleavage | N1 fragment + C-terminal fragment | - |
? | |
cellular prion protein | Mus musculus | knock out line has 51% of reduction in N1 formation | N1 fragment + C-terminal fragment | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
cell line | - |
Mus musculus | - |
mouse cell line | - |
Purification (Comment) | Organism |
---|---|
SDS-PAGE | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast cell line | embryonic knock out fibroblast for ADAM10 | Mus musculus | - |
HEK-293 cell | embryonic wild type cell line and overexpressing ADAM10 | Homo sapiens | - |
neuronal cell line | TSM1 cell line | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cellular prion protein | constitutive protein cleavage | Mus musculus | N1 fragment + C-terminal fragment | - |
? | |
cellular prion protein | constitutive protein cleavage | Homo sapiens | N1 fragment + C-terminal fragment | - |
? | |
cellular prion protein | knock out line has 51% of reduction in N1 formation | Mus musculus | N1 fragment + C-terminal fragment | - |
? |