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Literature summary for 3.4.24.80 extracted from

  • Buttner, F.H.; Hughes, C.E.; Margerie, D.; Lichte, A.; Tschesche, H.; Caterson, B.; Bartnik, E.
    Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan susbtrate rAgg1murt at the æaggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan (1998), Biochem. J., 333, 159-165.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
catalytic domain Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P50281
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage
-
Homo sapiens
-
cartilage articular Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aggrecan + H2O recombinant fusion protein with G332A mutation, substrate is cleaved at the aggrecanase site in its interglobular domain sequence segment, products are fragments with the following MW: 72 kDa, 66 kDA and 42 kDa Homo sapiens ?
-
?
recombinant mutated aggrecan fusion protein 1 + H2O
-
Homo sapiens ?
-
?