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Literature summary for 3.4.24.80 extracted from
- A Membrane-type-1 matrix metalloproteinase (MT1-MMP) - discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells (2015), PLoS ONE, 10, e116006.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-MMP-2 + H2O | Homo sapiens | - |
MMP-2 + MMP-2 propeptide | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P50281 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast carcinoma cell | - |
Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-MMP-2 + H2O | - |
Homo sapiens | MMP-2 + MMP-2 propeptide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| membrane type 1 matrix metalloproteinase | - |
Homo sapiens |
| MT1-MMP | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme promotes tumor progression by circumventing the collagen-induced up-regulation of the pro-apoptotic tumor suppressor BIK. The enzyme contributes to the inactivation of the DDR1-BIK signalling axis through the cleavage of collagen fibres and/or the alteration of DDR1 receptor signalling unit, without triggering a drastic remodelling of the transcriptome of MCF-7 cells | Homo sapiens |
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