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Literature summary for 3.4.24.80 extracted from
- Shedding of kidney injury molecule-1 by membrane-type 1 matrix metalloproteinase (2012), J. Biochem., 152, 425-432.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BB-94 | - |
Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 56000 | - |
x * 56000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CD44 + H2O | Homo sapiens | - |
? | - |
? | |
| Fibronectin + H2O | Homo sapiens | - |
? | - |
? | |
| growth differentiation factor-1 + H2O | Homo sapiens | - |
? | - |
? | |
| hepatocyte growth factor activator inhibitor-1 + H2O | Homo sapiens | - |
? | - |
? | |
| kidney injury molecule-1 + H2O | Homo sapiens | the enzyme cleaves and sheds the substrate's ectodomain | ? | - |
? | |
| Laminin-1 + H2O | Homo sapiens | - |
? | - |
? | |
| laminin-5 + H2O | Homo sapiens | - |
? | - |
? | |
| pro-MMP-2 + H2O | Homo sapiens | - |
MMP-2 + MMP-2 propeptide | - |
? | |
| stromal cell-derived factor 1 + H2O | Homo sapiens | - |
? | - |
? | |
| syndecan-1 + H2O | Homo sapiens | - |
? | - |
? | |
| transforming growth factor-beta + H2O | Homo sapiens | - |
? | - |
? | |
| Type I collagen + H2O | Homo sapiens | - |
? | - |
? | |
| Vitronectin + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P50281 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293T cell | - |
Homo sapiens | - |
| HT-1080 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CD44 + H2O | - |
Homo sapiens | ? | - |
? | |
| Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
| growth differentiation factor-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| hepatocyte growth factor activator inhibitor-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| kidney injury molecule-1 + H2O | the enzyme cleaves and sheds the substrate's ectodomain | Homo sapiens | ? | - |
? | |
| Laminin-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| laminin-5 + H2O | - |
Homo sapiens | ? | - |
? | |
| pro-MMP-2 + H2O | - |
Homo sapiens | MMP-2 + MMP-2 propeptide | - |
? | |
| stromal cell-derived factor 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| syndecan-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| transforming growth factor-beta + H2O | - |
Homo sapiens | ? | - |
? | |
| Type I collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| Vitronectin + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 56000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| membrane-type 1 matrix metalloproteinase | - |
Homo sapiens |
| MT1-MMP | - |
Homo sapiens |
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