Any feedback?
Literature summary for 3.4.24.80 extracted from
- Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase (2012), Cancer Sci., 103, 448-454.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| the catalytic domain (Tyr112-Val335) is expressed in Escherichia coli BL21 cells | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hepatocyte growth factor activator inhibitor-1 + H2O | Homo sapiens | the 66 kDa protein is cleaved to 58, 42, and 16 kDa fragments | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P50281 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| nickel chelating column chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293T cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hepatocyte growth factor activator inhibitor-1 + H2O | the 66 kDa protein is cleaved to 58, 42, and 16 kDa fragments | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| membrane-type 1 MMP | - |
Homo sapiens |
| MT1-MMP | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the enzyme is induced by collagen-gel culture or con-canavalin A treatment | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
