Cloned (Comment) | Organism |
---|---|
the catalytic domain (Tyr112-Val335) is expressed in Escherichia coli BL21 cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hepatocyte growth factor activator inhibitor-1 + H2O | Homo sapiens | the 66 kDa protein is cleaved to 58, 42, and 16 kDa fragments | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50281 | - |
- |
Purification (Comment) | Organism |
---|---|
nickel chelating column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hepatocyte growth factor activator inhibitor-1 + H2O | the 66 kDa protein is cleaved to 58, 42, and 16 kDa fragments | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
membrane-type 1 MMP | - |
Homo sapiens |
MT1-MMP | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is induced by collagen-gel culture or con-canavalin A treatment | up |
General Information | Comment | Organism |
---|---|---|
metabolism | cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase | Homo sapiens |