Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54000 | - |
x * 54000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50281 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oral squamous cell carcinoma cell | - |
Homo sapiens | - |
UT-SCC-9 cell | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 54000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
membrane type 1 matrix metalloproteinase | - |
Homo sapiens |
MT1-MMP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of MT1-MMP induces epithelial-to-mesenchymal transition and results in the acquisition of cancer stem cell-like properties in SCC-9 cells. Upon up-regulation of the enzyme, the cells undergo EMT, in which they presented a fibroblast-like phenotype and have a decreased expression of epithelial markers (E-cadherin, cytokeratin18 and beta-catenin) and an increased expression of mesenchymal markers (vimentin and fibronectin) | Homo sapiens |