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Literature summary for 3.4.24.80 extracted from

  • Yang, C.; Zhu, L.; Xu, X.; Ning, T.; Ye, J.; Liu, L.
    Membrane type 1 matrix metalloproteinase induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells (2013), BMC Cancer, 13, 171.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
x * 54000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P50281
-
-

Source Tissue

Source Tissue Comment Organism Textmining
oral squamous cell carcinoma cell
-
Homo sapiens
-
UT-SCC-9 cell
-
Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 54000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
membrane type 1 matrix metalloproteinase
-
Homo sapiens
MT1-MMP
-
Homo sapiens

General Information

General Information Comment Organism
physiological function overexpression of MT1-MMP induces epithelial-to-mesenchymal transition and results in the acquisition of cancer stem cell-like properties in SCC-9 cells. Upon up-regulation of the enzyme, the cells undergo EMT, in which they presented a fibroblast-like phenotype and have a decreased expression of epithelial markers (E-cadherin, cytokeratin18 and beta-catenin) and an increased expression of mesenchymal markers (vimentin and fibronectin) Homo sapiens