Any feedback?
Literature summary for 3.4.24.80 extracted from
- Membrane type 1 matrix metalloproteinase induces epithelial-to-mesenchymal transition in prostate cancer (2008), J. Biol. Chem., 283, 6232-6240.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in prostate cancer LNCaP cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| TIMP-2 | 10 nM | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Homo sapiens | 9986 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| E-cadherin + H2O | MT1-MMP sheds E-cadherin at cell-cell adherens junctions | Homo sapiens | ? | - |
? |  |
| Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | MT1-MMP plays an important role in early cancer dissemination by converting epithelial cells to migratory mesenchymal-like cells | Homo sapiens | ? | - |
? | |
| pro-MMP-2 + H2O | - |
Homo sapiens | MMP-2 + ? | - |
? | |
| Type I collagen + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| membrane type 1 matrix metalloproteinase | - |
Homo sapiens |
| MT1-MMP | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
