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Literature summary for 3.4.24.80 extracted from
- Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells (2006), J. Biol. Chem., 281, 37576-37585.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phorbol 12-myristate 13-acetate | - |
Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not inhibited by TIMP-1 | Homo sapiens | |
| TIMP-2 | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-431 cell | - |
Homo sapiens | - |
| HT-1080 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| extracellular matrix metalloproteinase inducer + H2O | - |
Homo sapiens | extracellular matrix metalloproteinase inducer fragment + ? | 22000 Da in length | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| membrane type 1 matrix metalloproteinase | - |
Homo sapiens |
| MMP-14 | - |
Homo sapiens |
| MT1-MMP | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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