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Literature summary for 3.4.24.80 extracted from

  • Hurst, D.R.; Schwartz, M.A.; Ghaffari, M.A.; Jin, Y.; Tschesche, H.; Fields, G.B.; Sang, Q.A.
    Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities (2004), Biochem. J., 377, 775-779.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
recombinant cdMT1-MMP expressed in Escherichia coli, recombinant deltaTM-MT1-MMP expressed in Pichia pastoris Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information mercaptosulfide and hydroxamate inhibitors Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys-N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-NH2 + H2O
-
Homo sapiens ?
-
?
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Ala-Gln-Ala-Val-N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-Arg-Ser-Ser-Arg-NH2 + H2O
-
Homo sapiens ?
-
?
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Ala-Nva-N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-Ala-Arg-NH2 + H2O
-
Homo sapiens ?
-
?
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-Ala-Arg-NH2 + H2O cdMT1-MMP is catalytically more efficient towards small peptide substrates than deltaTM-MT1-MMP and the haemopexin domain of MT1-MMP facilitates the hydrolysis of triple-helical substrates Homo sapiens ?
-
?
(7-methoxycoumarin-4-yl)acetyl-Pro-Lys-Pro-Leu-Ala-Leu-N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-Ala-Arg-NH2 + H2O
-
Homo sapiens ?
-
?
Gelatin + H2O rat-tail tendon type I collagen boiled for 5 min and denatured to gelatin, when degraded by deltaTM-MT1-MMP and cdMT1-MMP Homo sapiens ?
-
?
additional information rat-tail tendon type I collagen not degraded by cdMT1-MMP at 37°C Homo sapiens ?
-
?
N-hexanoyl((GP-4-hydroxy-L-proline)5GPK(7-methoxycoumarin-4-yl)acetyl)GPQGLRGQK(2,4-dinitrophenyl)GVR(GP-4-hydroxy-L-proline)5-NH2 + H2O
-
Homo sapiens N-hexanoyl((GP-4-hydroxy-L-proline)5GPK(7-methoxycoumarin-4-yl)acetyl)GPQGL + RGQK(2,4-dinitrophenyl)GVR(GP-4-hydroxy-L-proline)5-NH2
-
?
rat-tail tendon type I collagen + H2O degraded by deltaTM-MT1-MMP at 37°C Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
membrane type 1-matrix metalloproteinase
-
Homo sapiens
MMP-14
-
Homo sapiens
MT1-MMP
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information values generally lower for cdMT1-MMP when compared with those for deltaTM-MT1-MMP Homo sapiens