Cloned (Comment) | Organism |
---|---|
wild-type and various mutants: deletion of catalytic domain, deletion of POX domain, deletion of cytoplasmic tail, deletion of 8, 8 or 12 amino acids at C-terminus, all deletions except catalytic and PEX domain reduced internalization of the protein | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
L571A/L572A | mutation leads to reduced internalization of enzyme | Homo sapiens |
L571A/L572A/L578A/L579A | mutation leads to reduced internalization of enzyme | Homo sapiens |
L571A/L572A/Y573A | mutation leads to reduced internalization of enzyme, no effect on cell motility | Homo sapiens |
L578A/L579A | mutation leads to reduced internalization of enzyme | Homo sapiens |
S577A | internalization of enzyme is not affected, enhanced cell motility | Homo sapiens |
V582A | internalization of enzyme is not affected | Homo sapiens |
Y573A | mutation leads to reduced internalization of enzyme | Homo sapiens |
Y573A/L571A/L572A/L578A/L579A | mutation leads to reduced internalization of enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | transmembrane protein | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | involved in cell migration | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P50281 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | involved in cell migration | Homo sapiens | ? | - |
? | |
progelatinase A + H2O | - |
Homo sapiens | ? | - |
? |