Literature summary for 3.4.24.79 extracted from

Conover, C.A.; Mason, M.A.; Levine, J.A.; Novak, C.M.
Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype (2008), J. Endocrinol., 198, 599-605.

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Application

Application	Comment	Organism
molecular biology	mice born with the deletion of the gene for PAPP-A, a model of reduced local IGF activity, live approximately 30% longer than their wild-type littermates. Food intake, and total energy expenditure and resting energy expenditure as measured by calorimetry are not different between PAPP-A knockout and wild-type mice. There is an increase in spontaneous physical activity in PAPP-A knockout mice. Both wild-type and PAPP-A knockout mice exhibit mild insulin resistance with age. Oral glucose tolerance and insulin sensitivity are not significantly different between the two groups of mice, although there appeared to be a decrease in the average size of the pancreatic islets in PAPP-A knockout mice. Thus, neither reduced rate of living nor altered glucose-insulin homeostasis can be considered key determinants of the enhanced longevity of PAPP-A knockout mice	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
PAPP-A	-	Mus musculus
pregnancy-associated plasma protein-A	-	Mus musculus

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Release 2023.1 (January 2023)