Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme expression in fibroblasts is stimulated by pro-inflammatory cytokines involved in repair responses, especially TNFalpha and interleukin 1-beta, the stimulation is inhibited by resveratrol | Homo sapiens |
Application | Comment | Organism |
---|---|---|
diagnostics | PAPP-A is a circulating biomarker for acute coronary syndrome | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and anaylsis, sequence comparisons | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of enzyme knockout mice, dwarf phenotype with decreased body size and IGF-II deficiency, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Drosophila melanogaster | |
Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Mus musculus | |
Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Homo sapiens | |
Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Rattus norvegicus | |
Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Xenopus laevis | |
Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Caenorhabditis elegans | |
Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Danio rerio | |
Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Takifugu rubripes | |
Zn2+ | zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH | Tetraodon nigroviridis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IGF-binding protein-4 + H2O | Homo sapiens | i.e. IGFBP-4 | ? | - |
? | |
additional information | Homo sapiens | regulation of enzyme expression, e.g. by pro-inflammatory cytokines involved in repair responses, especially TNFalpha and interleukin 1-beta, the enzyme is involved in cardiovascular disease, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Danio rerio | - |
- |
- |
Drosophila melanogaster | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Takifugu rubripes | - |
- |
- |
Tetraodon nigroviridis | - |
- |
- |
Xenopus laevis | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the enzyme performs autocatalytic cleavage | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
artery | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
heart | coronary artery smooth muscle cells | Homo sapiens | - |
smooth muscle cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IGF-binding protein-4 + H2O | i.e. IGFBP-4 | Homo sapiens | ? | - |
? | |
additional information | regulation of enzyme expression, e.g. by pro-inflammatory cytokines involved in repair responses, especially TNFalpha and interleukin 1-beta, the enzyme is involved in cardiovascular disease, overview | Homo sapiens | ? | - |
? | |
additional information | domain structure and function, overview, the enzyme performs autocatalytic cleavage | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | primary sequence, structure motifs, and domain structure and function, the first 350 amino acid residues comprise the proteolytic domain, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PAPP-A | - |
Drosophila melanogaster |
PAPP-A | - |
Mus musculus |
PAPP-A | - |
Homo sapiens |
PAPP-A | - |
Rattus norvegicus |
PAPP-A | - |
Xenopus laevis |
PAPP-A | - |
Caenorhabditis elegans |
PAPP-A | - |
Danio rerio |
PAPP-A | - |
Takifugu rubripes |
PAPP-A | - |
Tetraodon nigroviridis |
pregnancy-associated plasma protein-A | - |
Drosophila melanogaster |
pregnancy-associated plasma protein-A | - |
Mus musculus |
pregnancy-associated plasma protein-A | - |
Homo sapiens |
pregnancy-associated plasma protein-A | - |
Rattus norvegicus |
pregnancy-associated plasma protein-A | - |
Xenopus laevis |
pregnancy-associated plasma protein-A | - |
Caenorhabditis elegans |
pregnancy-associated plasma protein-A | - |
Danio rerio |
pregnancy-associated plasma protein-A | - |
Takifugu rubripes |
pregnancy-associated plasma protein-A | - |
Tetraodon nigroviridis |