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Literature summary for 3.4.24.79 extracted from

  • Boldt, H.B.; Conover, C.A.
    Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs (2007), Growth Horm. IGF Res., 17, 10-18.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme expression in fibroblasts is stimulated by pro-inflammatory cytokines involved in repair responses, especially TNFalpha and interleukin 1-beta, the stimulation is inhibited by resveratrol Homo sapiens

Application

Application Comment Organism
diagnostics PAPP-A is a circulating biomarker for acute coronary syndrome Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and anaylsis, sequence comparisons Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of enzyme knockout mice, dwarf phenotype with decreased body size and IGF-II deficiency, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH Drosophila melanogaster
Zn2+ zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH Mus musculus
Zn2+ zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH Homo sapiens
Zn2+ zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH Rattus norvegicus
Zn2+ zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH Xenopus laevis
Zn2+ zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH Caenorhabditis elegans
Zn2+ zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH Danio rerio
Zn2+ zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH Takifugu rubripes
Zn2+ zinc endoprotease, the enzyme contains the zinc-binding consensus sequence HEXXHXXGXXH Tetraodon nigroviridis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IGF-binding protein-4 + H2O Homo sapiens i.e. IGFBP-4 ?
-
?
additional information Homo sapiens regulation of enzyme expression, e.g. by pro-inflammatory cytokines involved in repair responses, especially TNFalpha and interleukin 1-beta, the enzyme is involved in cardiovascular disease, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Danio rerio
-
-
-
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Takifugu rubripes
-
-
-
Tetraodon nigroviridis
-
-
-
Xenopus laevis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the enzyme performs autocatalytic cleavage Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
artery
-
Homo sapiens
-
fibroblast
-
Homo sapiens
-
heart coronary artery smooth muscle cells Homo sapiens
-
smooth muscle cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IGF-binding protein-4 + H2O i.e. IGFBP-4 Homo sapiens ?
-
?
additional information regulation of enzyme expression, e.g. by pro-inflammatory cytokines involved in repair responses, especially TNFalpha and interleukin 1-beta, the enzyme is involved in cardiovascular disease, overview Homo sapiens ?
-
?
additional information domain structure and function, overview, the enzyme performs autocatalytic cleavage Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More primary sequence, structure motifs, and domain structure and function, the first 350 amino acid residues comprise the proteolytic domain, overview Homo sapiens

Synonyms

Synonyms Comment Organism
PAPP-A
-
Drosophila melanogaster
PAPP-A
-
Mus musculus
PAPP-A
-
Homo sapiens
PAPP-A
-
Rattus norvegicus
PAPP-A
-
Xenopus laevis
PAPP-A
-
Caenorhabditis elegans
PAPP-A
-
Danio rerio
PAPP-A
-
Takifugu rubripes
PAPP-A
-
Tetraodon nigroviridis
pregnancy-associated plasma protein-A
-
Drosophila melanogaster
pregnancy-associated plasma protein-A
-
Mus musculus
pregnancy-associated plasma protein-A
-
Homo sapiens
pregnancy-associated plasma protein-A
-
Rattus norvegicus
pregnancy-associated plasma protein-A
-
Xenopus laevis
pregnancy-associated plasma protein-A
-
Caenorhabditis elegans
pregnancy-associated plasma protein-A
-
Danio rerio
pregnancy-associated plasma protein-A
-
Takifugu rubripes
pregnancy-associated plasma protein-A
-
Tetraodon nigroviridis