Application | Comment | Organism |
---|---|---|
medicine | enhancing IGF bioavailability by PAPP-A can be a powerful strategy in the treatment of certain metabolic diseases such as osteoporosis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of the enzyme in transgenic mice, expression of FLAG-tagged enzyme in primary mouse osteoblasts | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of transgenic mice overexpressing the enzyme, osteoblasts of transgenic mice show increased IGFBP-4 proteolysis and increased free IGF-I concentration. Calvarial bone thickness, bone marrow cavity, and skull bone mineral density are significantly increased in transgenic mice, bone size-related parameters in femur and tibia such as total bone area and periosteal circumference are significantly increased in transgenic mice. Bone formation rate and osteoid surface are increased by more than 2fold, whereas bone resorbing surface is unaffected. These anabolic effects are sustained with aging, phenotype overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IGF-binding protein-2 + H2O | Homo sapiens | - |
? | - |
? | |
IGF-binding protein-4 + H2O | Homo sapiens | - |
? | - |
? | |
IGF-binding protein-5 + H2O | Homo sapiens | - |
? | - |
? | |
additional information | Homo sapiens | PAPP-A enhances IGF action by increasing its bioavailability, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
osteoblast | expression analysis, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IGF-binding protein-2 + H2O | - |
Homo sapiens | ? | - |
? | |
IGF-binding protein-4 + H2O | - |
Homo sapiens | ? | - |
? | |
IGF-binding protein-5 + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | PAPP-A enhances IGF action by increasing its bioavailability, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAPP-A | - |
Homo sapiens |
pregnancy-associated plasma protein-A | - |
Homo sapiens |