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Literature summary for 3.4.24.79 extracted from
- Surface association of pregnancy-associated plasma protein-A accounts for its colocalization with activated macrophages (2007), Am. J. Physiol. Heart Circ. Physiol., 292, H994-H1000.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | a mutant chimeric variant of PAPP-A, which is replaced in part by PAPP-A2 sequences, retains functionality as a protease but is unable to bind surface-associated glycosaminoglycan and shows no macrophage association or internalization | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | surface association of PAPP-A accounts for its colocalization with activated macrophages in human atherosclerotic plaque, immunohistochemic analysis, overview | Homo sapiens | 9986 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| IGF-binding protein-4 + H2O | Homo sapiens | i.e. IGFBP-4 | ? | - |
? |  |
| additional information | Homo sapiens | activated macrophage regulation of PAPP-A expression, co-localization of macophages and PAPP-A is involved in development of vulnerable plaques, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| IGF-binding protein-4 + H2O | i.e. IGFBP-4 | Homo sapiens | ? | - |
? | |
| additional information | activated macrophage regulation of PAPP-A expression, co-localization of macophages and PAPP-A is involved in development of vulnerable plaques, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAPP-A | - |
Homo sapiens |
| pregnancy-associated plasma protein-A | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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