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Literature summary for 3.4.24.79 extracted from

  • Qin, X.; Byun, D.; Lau, K.H.W.; Baylink, D.J.; Mohan, S.
    Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease (2000), Arch. Biochem. Biophys., 379, 209-216.
    View publication on PubMed
Search for more literature for 3.4.24.79

Activating Compound

Activating Compound Comment Organism Structure
IGF PAPP-A activity is dependent on presence of insulin-like growth factor-II Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens interaction between insulin-like growth factor-II and insulin-like growth factor binding protein-4 is required for proteolysis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Cleavage of the Met135-/-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-/-Lys bond in IGFBP-5 mechanism Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
osteoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin-like growth factor binding protein-4 + H2O mutants of insulin-like growth factor binding protein-4 Homo sapiens ?
-
 ?
additional information cleavage of insulin-like growth factor binding protein-4 occurs only in presence of insulin-like growth factor-II Homo sapiens ?
-
 ?
additional information interaction between insulin-like growth factor-II and insulin-like growth factor binding protein-4 is required for proteolysis Homo sapiens ?
-
 ?