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Literature summary for 3.4.24.79 extracted from

  • Lawrence, J.B.; Bale, L.K.; Haddad, T.C.; Clarkson, J.T.; Conover, C.A.
    Characterization and partial purification of the insulin-like growth factor (IGF)-dependent IGF binding protein-4-specific protease from human fibroblast conditioned media (1999), Growth Horm. IGF Res., 9, 25-34.
    View publication on PubMed
Search for more literature for 3.4.24.79

General Stability

General Stability Organism
high salt condition, SDS, or beta-mercaptoethanol inhibit Homo sapiens
Triton X-100, Tween-20, NP-40, sodium azide, glycerol do not affect enzyme activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
beta-mercaptoethanol
-
 Homo sapiens
SDS
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble secreted Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ Zn2+ binding metalloprotease Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
400000
-
 more than, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin-like growth factor binding protein-4 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Storage Stability

Storage Stability Organism
-30°C, 1 year, no loss of activity Homo sapiens
4°C, 3 days, no loss of activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin-like growth factor binding protein-4 + H2O
-
 Homo sapiens ?
-
 ?
additional information cleavage of insulin-like growth factor binding protein-4 occurs only in presence of insulin-like growth factor-II Homo sapiens ?
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
 10 min, no loss of activity Homo sapiens
55
-
 10 min, no loss of activity Homo sapiens
70 95 10 min, complete inactivation Homo sapiens