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Literature summary for 3.4.24.75 extracted from
- Lysostaphin: A staphylococcal bacteriolysin with potential clinical applications (2010), Pharmaceuticals, 3, 1139-1161.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | lysostaphin is an antistaphylococcal agent. The enzyme is efficacious in the treatment of bovine mastitis caused by staphylococci | Staphylococcus simulans |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Staphylococcus simulans |
General Stability
| General Stability | Organism |
|---|---|
| lysostaphin is relatively stable when conjugated with polyethylene glycol and it maintains its activity in human serum | Staphylococcus simulans |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | contains zinc | Staphylococcus simulans |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 27000 | - |
1 * 27000, calculated from amino acid sequence | Staphylococcus simulans |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Staphylococcus simulans | lysostaphin exhibits a high degree of antistaphylococcal bacteriolytic activity, being inactive against bacteria of all other genera. The cell-wall degrading activity of lysostaphin is primarily due to a glycylglycine endopeptidase activity. Staphylococcus simulans biovar staphylolyticus peptidoglycan is resistant to the hydrolytic activity of lysostaphin, since the cells produce a resistance factor that causes the incorporation of Ser residues into the third and fifth positions of the cell wall cross bridges | ? | - |
? | |
| Peptidoglycan + H2O | Staphylococcus simulans | cleaves Gly-Gly bonds in peptidoglycans | Fragments of peptidoglycan | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus simulans | P10547 | Staphylococcus simulans biovar staphylolyticus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | lysostaphin exhibits a high degree of antistaphylococcal bacteriolytic activity, being inactive against bacteria of all other genera. The cell-wall degrading activity of lysostaphin is primarily due to a glycylglycine endopeptidase activity. Staphylococcus simulans biovar staphylolyticus peptidoglycan is resistant to the hydrolytic activity of lysostaphin, since the cells produce a resistance factor that causes the incorporation of Ser residues into the third and fifth positions of the cell wall cross bridges | Staphylococcus simulans | ? | - |
? | |
| Peptidoglycan + H2O | cleaves Gly-Gly bonds in peptidoglycans | Staphylococcus simulans | Fragments of peptidoglycan | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 27000, calculated from amino acid sequence | Staphylococcus simulans |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Staphylococcus simulans |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Staphylococcus simulans | calculated from amino acid sequence | - |
9.5 |
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