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Literature summary for 3.4.24.74 extracted from

  • Sears, C.L.; Buckwold, S.L.; Shin, J.W.; Franco, A.A.
    The C-terminal region of Bacteroides fragilis toxin is essential to its biological activity (2006), Infect. Immun., 74, 5595-5601.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.74

Protein Variants

Protein Variants Comment Organism
A394E mutation does not affect BFT processing or secretion Bacteroides fragilis
additional information C-terminal truncation mutants BFT-C2, BFT-C4, BFT-C7, BFT-C8, BFT-C9, BFT-C11, BFT-C18, deletion of only 2 amino acid residues at the C-terminus significantly reduces BFT biological activity and deletion of eight or more amino acid residues obliterated BFT biological activity, BFT mutants lacking seven or fewer amino acid residues in the C-terminal region are processed and expressed similar to wild-type BFT Bacteroides fragilis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
 Western blot analysis of cell-free culture supernatants of strain NCTC 9343 expressing mutants BFT-C2, BFT-C4 and BFT-A394E, and of whole cell lysates in preperations of strain NCTC 9343 expressing wild type BFT Bacteroides fragilis
44000
-
 unprocessed enzyme, Western blot analysis of whole cell lysates in preperations of strain NCTC 9343 expressing wild type BFT Bacteroides fragilis

Organism

Organism UniProt Comment Textmining
Bacteroides fragilis
-
 strain 086-5443-2-2, strain NCTC 9343
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bacteroides fragilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
E-cadherin + H2O
-
 Bacteroides fragilis ?
-
 ?

Synonyms

Synonyms Comment Organism
Bacteroides fragilis toxin
-
 Bacteroides fragilis
BFT
-
 Bacteroides fragilis