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Literature summary for 3.4.24.73 extracted from

  • Sugiki, M.; Maruyama, M.; Yoshida, E.; Mihara, H.; Kamiguti, A.S.; Theakston, R.D.G.
    Enhancement of plasma fibrinolysis in vitro by jararhagin, the main haemorrhagic metalloproteinase in Bothrops jararaca venom (1995), Toxicon, 33, 1605-1617.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc zinc metalloproteinase Bothrops jararaca
Zinc zinc binding domain Bothrops jararaca

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
1 * 52000, Bothrops jararaca, SDS-PAGE Bothrops jararaca

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bothrops jararaca main hemorrhagic metalloproteinase in Bothrops jararaca venom ?
-
?

Organism

Organism UniProt Comment Textmining
Bothrops jararaca
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bothrops jararaca

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Bothrops jararaca
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha2-Plasmin inhibitor + H2O
-
Bothrops jararaca Inactivated alpha2-plasmin inhibitor
-
?
additional information possesses proteolytic and hemorrhagic activity Bothrops jararaca ?
-
?
additional information in vitro induces strongly fibrinolytic activity in plasma of guinea pig, horse, dog, rabbit and human (not in plasma of rat, mouse, hamster, goat, sheep, pig or bovine), it increases tissue-type plasminogen activator activity by dissociation of a complex of this activator with type 1 plasminogen activator inhibitor and inactivation of alpha2-plasmin inhibitor Bothrops jararaca ?
-
?
additional information main hemorrhagic metalloproteinase in Bothrops jararaca venom Bothrops jararaca ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 52000, Bothrops jararaca, SDS-PAGE Bothrops jararaca

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bothrops jararaca