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Literature summary for 3.4.24.72 extracted from

  • Lin, X.; Liang, X.; Tang, J.; Chen, J.; Qiu, P.; Yan, G.
    The effect of the fibrinolytic enzyme FIIa from Agkistrodon acutus venom on acute pulmonary thromboembolism (2011), Acta Pharmacol. Sin., 32, 239-244.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine the enzyme effectively protects against acute pulmonary thromboembolism via degradation of thrombi with less activation of plasminogen Deinagkistrodon acutus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ essential for hydrolytic activity Deinagkistrodon acutus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibrin + H2O Deinagkistrodon acutus the enzyme has the ability to directly degrade fibrin in vitro and effectively dissolve thrombi in vivo without activating plasminogen or influencing the activities of tissue plasminogen activator and plasminogen activator inhibitor-1 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Deinagkistrodon acutus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Deinagkistrodon acutus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibrin + H2O the enzyme has the ability to directly degrade fibrin in vitro and effectively dissolve thrombi in vivo without activating plasminogen or influencing the activities of tissue plasminogen activator and plasminogen activator inhibitor-1 Deinagkistrodon acutus ?
-
 ?

Synonyms

Synonyms Comment Organism
FIIa
-
 Deinagkistrodon acutus