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Literature summary for 3.4.24.72 extracted from

  • Toombs, C.F.; Deitcher, S.R.
    Nonclinical and clinical characterization of a novel acting thrombolytic: alfimeprase (2006), Toxin Rev., 25, 379-392.
No PubMed abstract available
Search for more literature for 3.4.24.72

Application

Application Comment Organism
pharmacology alfimeprase is a potential therapeutic agents in thrombosis therapy, clinical indications and studies, overview Agkistrodon contortrix contortrix

Cloned(Commentary)

Cloned (Comment) Organism
expression of the wild-type fibrolase and a truncated enzyme form, alfimeprase Agkistrodon contortrix contortrix

Inhibitors

Inhibitors Comment Organism Structure
alpha2-Macroglobulin rapid, irreversible inhibition by physical entrapment Agkistrodon contortrix contortrix

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Agkistrodon contortrix contortrix
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates Agkistrodon contortrix contortrix
Zn2+ the zinc binding region spans amino acids 139-159 Agkistrodon contortrix contortrix

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Fibrin + H2O Agkistrodon contortrix contortrix fibrinolytic activity ?
-
 ?
fibrinogen + H2O Agkistrodon contortrix contortrix fibrinogenolytic activity fibrin + propeptide
-
 ?
additional information Agkistrodon contortrix contortrix thrombolysis in animals by snake venom alfimeprase, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Agkistrodon contortrix contortrix
-
 southern copperhead snake
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Agkistrodon contortrix contortrix
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 blood clot lysis in vitro model, overview Agkistrodon contortrix contortrix

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibrin + H2O fibrinolytic activity Agkistrodon contortrix contortrix ?
-
 ?
Fibrin + H2O fibrinolytic activity cleaving the Lys413-Leu414 bond Agkistrodon contortrix contortrix ?
-
 ?
fibrinogen + H2O fibrinogenolytic activity Agkistrodon contortrix contortrix fibrin + propeptide
-
 ?
fibrinogen + H2O human substrate, fibrinogenolytic activity Agkistrodon contortrix contortrix fibrin + propeptide
-
 ?
additional information thrombolysis in animals by snake venom alfimeprase, overview Agkistrodon contortrix contortrix ?
-
 ?
additional information alfimeprase is the recombinant truncated form of fibrolase from snake venom lacking the two N-terminal amino acids Glu and Gln Agkistrodon contortrix contortrix ?
-
 ?

Subunits

Subunits Comment Organism
More alfimeprase is the recombinant truncated form of fibrolase from snake venom lacking the two N-terminal amino acids Glu and Gln, fibrolase N-terminus: SFPQR, alfimeprase N-terminus: EQRFPQR Agkistrodon contortrix contortrix

Synonyms

Synonyms Comment Organism
Alfimeprase
-
 Agkistrodon contortrix contortrix

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Agkistrodon contortrix contortrix