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Literature summary for 3.4.24.7 extracted from

  • Chen, B.; Li, R.; Yan, N.; Chen, G.; Qian, W.; Jiang, H.L.; Ji, C.; Bi, Z.G.
    Astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-beta/Smad signaling suppression and inhibiting matrix metalloproteinase-1 (2015), Mol. Med. Rep., 11, 3344-3348 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.7

Application

Application Comment Organism
drug development MMP-1 enzyme inhibitor astragaloside IV is a potential agent against skin photoaging Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene MMP-1, quantitative RT-PCR expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
astragaloside IV AST, inhibits matrix metalloproteinase-1 in photoaging skin. Astragaloside IV is one of the major active compoxadnents extracted from Astragalus membranaceus. Effects of AST against collagen reducxadtion in UV-induced skin aging in human skin fibroblasts, and mechanism of multiple anti-photoaging effects, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P03956
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-
skin
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-1
-
 Homo sapiens
MMP-1
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-beta/Smad signaling suppression and inhibiting matrix metalloproteinase-1. Transforming growth factor beta type II protein and COL1 mRNA decreased but MMP-1 and Smad7 levels increased in the photoaging model group, which is reversed by topical application of AST. AST prevents collagen reduction from UV irradiation in photoaging skin Homo sapiens