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Literature summary for 3.4.24.7 extracted from
- Methotrexate modulates the expression of MMP-1 and type 1 collagen in dermal fibroblast (2015), Mol. Cell. Biochem., 409, 213-224 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | the enzyme is secreted | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Collagen type I + H2O | Homo sapiens | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P03956 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | primary human neonatal dermal fibroblasts | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Collagen type I + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MMP-1 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | methotrexate (MTX) increases the expression of MMP-1 in primary human neonatal, adult, and hypertrophic scar fibroblasts by 1.5fold 72 h after treatment with 50-500 ng/ml MTX | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | methotrexate (MTX) significantly reduces collagen type I production in different strains of fibroblasts derived from neonatal, adult, and hypertrophic scar tissues, while under the same experimental conditions, it increases the expression of MMP-1. Possible involvement of MTX-induced extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in MMP-1 production. Activation of ERK1/2 pathway plays an important role in MTX-induced MMP-1 expression in primary human dermal fibroblasts | Homo sapiens |
| physiological function | MMP-1 is one of the key regulators of the overall quantity of type I procollagen deposited by fibroblasts during scar formation. It increases collagen degradation in the extracellular matrix (ECM) | Homo sapiens |
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