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Literature summary for 3.4.24.7 extracted from

  • Lu, W.; Zhu, J.; Zou, S.; Li, X.; Huang, J.
    The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors (2013), J. Enzyme Inhib. Med. Chem., 28, 741-746.
    View publication on PubMed

Application

Application Comment Organism
synthesis improved method for high-level expression of soluble human MMP-1 catalytic domain in Escherichia coli Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
fisetin mixed-type inhibition Homo sapiens
quercetin
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
2,4-dinitrophenyl-Pro-beta-cyclohexyl-Ala-Gly-Cys(Me)-His-Ala-Lys(N-methyl-2-aminobenzoyl)-NH2 pH 7.5, 40°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ optimum concentration 5 mM Homo sapiens
Zn2+ in presence of 5 mM Ca2+, optimum concentration 0.001 mM, decrease in activity above Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000
-
x * 21000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P03956
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-dinitrophenyl-Pro-beta-cyclohexyl-Ala-Gly-Cys(Me)-His-Ala-Lys(N-methyl-2-aminobenzoyl)-NH2 + H2O
-
Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 21000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
mmp1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00135
-
fisetin pH 7.5, 40°C Homo sapiens
0.00149
-
quercetin pH 7.5, 40°C Homo sapiens