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Literature summary for 3.4.24.7 extracted from

  • Struewing, I.T.; Durham, S.N.; Barnett, C.D.; Mao, C.D.
    Enhanced endothelial cell senescence by lithium-induced matrix metalloproteinase-1 expression (2009), J. Biol. Chem., 284, 17595-17606.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
diagnostics MMP-1 is an inflammation and senescent cell marker Homo sapiens
diagnostics MMP-1 is an inflammation and senescent cell marker Bos taurus

Protein Variants

Protein Variants Comment Organism
additional information although increased MMP-1 levels are usually associated with angiogenesis in enabled proliferative endothelial cells, the exogenous addition of activated MMP-1 on lithium-arrested endothelial cells increases the number of endothelial cells positive for the senescent-associated-beta-galactosidase marker. Conversely, downregulation of MMP-1 expression by small interfering RNAs blunts the lithium-dependent increase in senescent-associated-beta-galactosidase positive cells. Lithium-induced MMP-1 expression is mediated neither by GSK3beta inhibition nor beta-catenin stabilization, lithium-dependent cell cycle arrest and the cell senescent phenotype in aortic endothelial cells are not triggered by inhibition of the inositol phosphate cycle. Induction molecular mechanism, overview Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Type I collagen + H2O Homo sapiens
-
?
-
?
Type I collagen + H2O Bos taurus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aortic endothelial cell
-
Bos taurus
-
commercial preparation recombinant MMP-1 Homo sapiens
-
endothelial cell primary Homo sapiens
-
fibroblast
-
Homo sapiens
-
keratinocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Type I collagen + H2O
-
Homo sapiens ?
-
?
Type I collagen + H2O
-
Bos taurus ?
-
?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-1
-
Homo sapiens
matrix metalloproteinase-1
-
Bos taurus
MMP-1
-
Homo sapiens
MMP-1
-
Bos taurus

Expression

Organism Comment Expression
Homo sapiens lithium specifically induces a rapid and pronounced up-regulation of MMP-1 at the mRNA and protein levels, whereas the induction of two the other senescent cell markers plasminogen activator inhibitor-1 and interleukin-8 is either delayed or weak, respectively. Lithium affects MMP-1 expression mainly at the transcriptional level but neither the AP1/Ets regulatory sites nor the redox sensitive -1607/2G site in MMP-1 promoter are involved in lithium-dependent MMP-1 regulation up

General Information

General Information Comment Organism
physiological function lithium-induced MMP-1 may participate in the reinforcement of endothelial cell senescence revealing a novel mechanism for lithium-induced tissue remodeling Homo sapiens
physiological function lithium-induced MMP-1 may participate in the reinforcement of endothelial cell senescence revealing a novel mechanism for lithium-induced tissue remodeling Bos taurus