Application | Comment | Organism |
---|---|---|
diagnostics | MMP-1 is an inflammation and senescent cell marker | Homo sapiens |
diagnostics | MMP-1 is an inflammation and senescent cell marker | Bos taurus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | although increased MMP-1 levels are usually associated with angiogenesis in enabled proliferative endothelial cells, the exogenous addition of activated MMP-1 on lithium-arrested endothelial cells increases the number of endothelial cells positive for the senescent-associated-beta-galactosidase marker. Conversely, downregulation of MMP-1 expression by small interfering RNAs blunts the lithium-dependent increase in senescent-associated-beta-galactosidase positive cells. Lithium-induced MMP-1 expression is mediated neither by GSK3beta inhibition nor beta-catenin stabilization, lithium-dependent cell cycle arrest and the cell senescent phenotype in aortic endothelial cells are not triggered by inhibition of the inositol phosphate cycle. Induction molecular mechanism, overview | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Type I collagen + H2O | Homo sapiens | - |
? | - |
? | |
Type I collagen + H2O | Bos taurus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aortic endothelial cell | - |
Bos taurus | - |
commercial preparation | recombinant MMP-1 | Homo sapiens | - |
endothelial cell | primary | Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Type I collagen + H2O | - |
Homo sapiens | ? | - |
? | |
Type I collagen + H2O | - |
Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-1 | - |
Homo sapiens |
matrix metalloproteinase-1 | - |
Bos taurus |
MMP-1 | - |
Homo sapiens |
MMP-1 | - |
Bos taurus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | lithium specifically induces a rapid and pronounced up-regulation of MMP-1 at the mRNA and protein levels, whereas the induction of two the other senescent cell markers plasminogen activator inhibitor-1 and interleukin-8 is either delayed or weak, respectively. Lithium affects MMP-1 expression mainly at the transcriptional level but neither the AP1/Ets regulatory sites nor the redox sensitive -1607/2G site in MMP-1 promoter are involved in lithium-dependent MMP-1 regulation | up |
General Information | Comment | Organism |
---|---|---|
physiological function | lithium-induced MMP-1 may participate in the reinforcement of endothelial cell senescence revealing a novel mechanism for lithium-induced tissue remodeling | Homo sapiens |
physiological function | lithium-induced MMP-1 may participate in the reinforcement of endothelial cell senescence revealing a novel mechanism for lithium-induced tissue remodeling | Bos taurus |