Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.7 extracted from

  • Yang, B.; Ji, C.; Kang, J.; Chen, W.; Bi, Z.; Wan, Y.
    Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts (2009), Int. J. Mol. Med., 23, 555-560.
    View publication on PubMed
Search for more literature for 3.4.24.7

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular MMP-1 is secreted by skin fibroblasts Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-
skin
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-1
-
 Homo sapiens
MMP-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens UVA and UVB irradiation of dermal fibroblasts in vitro or human skin in vivo induces MMP-1 expression. MMP-1 expression and secretion induced by UV-B irradiation is inhibited by trans-zeatin, a cytokinin from Zea mays, and by PD98059, an ERK inhibitor, by SP600125, a JNK inhibitor and by SB203580, a p38 MAPK inhibitor. trans-Zeatin also inhibits UVB-induced ERK, JNK, p38 MAPK and c-Jun phosphorylation up

General Information

General Information Comment Organism
physiological function MMP-1 is implicated in the degradation of human skin matrix proteins such as collagen and other components of extracellular matrix Homo sapiens